| Name | Type | Zone |
| Sacrificial Altar | Point of Interest | Thunder River |
| Saddlebags | Quest Object | Conall's Valley |
| Sailor's Den | Zone Entrance | Old Tarantia |
| Salt and Spices | Quest Object | Khopsef Province |
| Sanctum of the Burning Souls | Zone Entrance | Wild Lands of Zelata |
| Sandstone | Resource | Lacheish Plains, Poitain, Purple Lotus Swamp, Khopsef Province |
| Scorpion Cave | Zone Entrance | Kheshatta |
| Scorpion Cult | Point of Interest | Kheshatta |
| Scorpion Shelf Spring | Quest Object | Kheshatta |
| Seadog Mansion | Zone Entrance | City of Tortage |
| Sealed Letter | Quest Object | Khemi |
| Search for Telung in the Spider Caverns | Quest Goal | Conall's Valley |
| Search for the Scouts | Quest Goal | Field of the Dead |
| Search Sequella's Corpse | Quest Goal | Aztel's Approach |
| Serpent's Head Inn | Zone Entrance | Khemi |
| Set Fire to the Lookout Post | Quest Goal | Eiglophian Mountains |
| Set Fires to the Torches of Eiglophian | Quest Goal | Field of the Dead |
| Settlement of Dinog | Point of Interest | Eiglophian Mountains |
| Silver Bracelet | Quest Object | Cannibal Cave |
| Silver Vein | Resource | Khopsef Province, Lacheish Plains, Poitain, Purple Lotus Swamp |
| Skammenstein | Point of Interest | Aztel's Approach |
| Slay a Cannibal and take his corpse | Quest Goal | Eiglophian Mountains |
| Smuggler's Spring | Quest Object | Kheshatta |
| Southern Plateus | Point of Interest | Kheshatta |
| Spice Sand | Quest Object | Kheshatta |
| Spider Caverns | Zone Entrance | Conall's Valley |
| Spool of Thread | Quest Object | Tortage Beach |
| Steal a Map from the Mercenaries | Quest Goal | Thunder River |
| Steal a Plan from the Mercenaries | Quest Goal | Thunder River |
| Steal Their Weapons | Quest Object | Kheshatta |
| Stockade Gate | Quest Object | Field of the Dead |
| Stolen Gems | Quest Object | Old Tarantia |
| Stolen Jewelry | Quest Object | Tortage Underhalls Day |
| Stolen Pelt | Quest Object | Tortage Underhalls Day |
| Stone Brick | Quest Object | Tortage Beach |
| Strike the Cymbal of Doom | Quest Goal | Aztel's Approach |
| Strongbox (Bearer) | Quest Object | Field of the Dead |
| A Sword | Quest Object | Eiglophian Mountains |
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